Correlazione tra immagini RMN e dati clinici nella malattia di Meniere (articolo cinese)

  1. Laryngoscope. 2020 Feb 21. doi: 10.1002/lary.28576. [Epub ahead of print]

The Correlation Between Endolymphatic Hydrops and Clinical Features of Meniere Disease.

  1. Zhang W1, Hui L2, Zhang B1, Ren L1, Zhu J1, Wang F2, Li S1.

  2. Author information

  3. Abstract OBJECTIVES: The purpose of this study was to investigate the grades of endolymphatic hydrops determined by gadolinium-contrast magnetic resonance (MR) and correlation to the clinical features in patients with Meniere disease. STUDY DESIGN: Prospective study. METHODS: A total of 24 patients suffering from unilateral Meniere disease with either definite or probable clinical diagnosis were included. The duration of vertigo, duration of tinnitus, duration of vertigo attacks, hearing thresholds, and canal paresis (CP) value of caloric tests were assessed. Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (MRI) was performed 4 hours after intravenous injection of double dose of gadobutrol (Gd) to show endolymph and perilymph, and the grades of endolymphatic hydrops were measured. Additionally, the correlation between clinical features and the grades of endolymphatic hydrops of cochlea and vestibular were evaluated. RESULTS: Different grades of the endolymphatic hydrops in the impaired ear were revealed by MRI. The Spearman correlation showed a strong correlation between the hearing thresholds of low, middle, and high tone and the grades of cochlea and vestibular hydrops (P < .05); However, no significant correlation between the duration of vertigo, duration of tinnitus, duration of vertigo attacks, CP value, and endolymphatic hydrops was determined (P > .05). CONCLUSION: By visualizing the endolymph and perilymph of inner ear in patients with Meniere disease assisted with intravenous injection of double doses of Gd, the grades of endolymphatic hydrops could be assessed. As a result, the grades of endolymphatic hydrops in patients with Meniere disease can be used to predict the level of hearing impairment. LEVEL OF EVIDENCE: 4 Laryngoscope, 2020. © 2020 The American Laryngological, Rhinological and Otological Society, Inc.

  4. KEYWORDS: MRI; Meniere disease; clinical features; endolymphatic hydrops; gadobutrol

  5. PMID: 32083730 DOI: 10.1002/lary.28576

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